Aspirantskiy Vestnik Povolzhiya

The Journal «Aspirantskiy Vestnik Povolzhiya» publish original research articles, scientific reviews, critical reviews, opinions and short communications which correspond to the following specialities:

  • Clinical Medicine
  • Preventive Medicine
  • Medical and Life Sciences
  • Pharmaceutical Sciences
  • Philosophical Sciences

The journal is included in the Russian Science Citation Index and in the list of leading peer-reviewed scientific journals for publication of scientific results of dissertations in candidacy for a Doctoral and Candidate of Sciences Degrees, approved by the Presidium of the Higher Attestation Commission of the Ministry of Education and Science of the Russian Federation (HAC).


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Current Issue

Vol 21, No 1-2 (2021)

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Clinical Medicine

Practical experience in using elastic bands in prosthodontics
Postnikov M.A., Bulycheva D.S., Bulycheva E.A., Valeev E.R.
  • AIM: The aim of the study was to investigate the effectiveness of combined treatment with elastic bands and splints in patients with masticatory muscle parafunction.

MATERIALS AND METHODS: 52 people (15 men and 37 women), suffered from masticatory muscle parafunction, were examined. The diagnosis was made on the basis of clinical and instrumental (electromyography) methods. Pain intensity was determined by using the visual-analog scale. The control group consists of 31 healthy people aged 16 to 31 years. Preliminary treatment of the patients of the main group was carried out by the use of the proposed method (combined treatment with elastic bands and splints).

RESULTS: It was found that the proposed method provides reliable (Z1-3 = –6.40, p1-3 = 0.01) reducing of pain intensity in masticatory muscles by the end of second week of therapy (from 8.17 ± 0.6 to 4.54 ± 0.5 points by the visual-analog scale). It was confirmed by reliable decrease of the bioelectric activity of masticatory muscles. The data for right masseter muscle was 5.7 ± 0.14 mkV (Z = –6.30, p = 0.015) and for the left one was 5.8 ± 0.21 mkV (Z = –6.29, p = 0.01); for right temporal muscle it was 4.1 ± 0.19 mkV (Z = –6.39, p = 0.01) and for left one it was 4.3 ± 0.18 mkV (Z = –6.28, p = 0.015).

CONCLUSIONS: The proposed method allows to achieve reliable decrease of the pain intensity in patients with masticatory muscle parafunction.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):9-14
pages 9-14 views
Analysis of the stress-strain state of a digital model of a reconstructive lyophilized allogeneic bone implant with the change in its design features
Ippolitov A.A., Popov N.V.
  • BACKGROUND: The favorable outcome after the restoration of bone loss in the jaws depends on many factors. Thus, one of the key factors is the data on the mechanical and biophysical characteristics of the used bone implants, ignorance of which often jeopardizes the successful treatment of dental patients.

AIM: To carry out a comparative experimental analysis of the stress-strain state of a digital model of a reconstructive lyophilized allogeneic bone implant with a change in its design characteristics.

MATERIALS AND METHODS: To determine the biomechanical indicators of integrity preservation, the analysis of the stress-strain state of mathematical models of a reconstructive cylindrical implant and a reconstructive implant made of lyophilized allogenic material was carried out under equal conditions using the finite element method.

RESULTS: As a result of the analysis of the stress-strain state of digital 3D models of reconstructive bone implants of two types, stress distributions according to von Mises (equivalent stresses) caused by the action of given loads were obtained. During the study, data on the margin of safety of reconstructive implants were obtained.

CONCLUSIONS: The capabilities of modern computer software make it possible to expand the possibilities of bone augmentation of the alveolar bone tissue of the jaws with simultaneous dental implantation, allowing analytically to find the optimal parameters of the used materials, to choose the magnitude and direction of force during their installation, and also to predict their behavior in the postoperative period.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):15-20
pages 15-20 views
Experience professional oral hygiene based on the GBT protocol in patients with hemophilia
Postnikov M.A., Dudina S.E., Tiunova N.V., Shukhorova Y.A., Fedoseikina I.V.
  • The incidence of inflammatory diseases of the oral cavity in patients with hereditary coagulopathy — hemophilia, as well as domestic and foreign experience of professional hygiene in persons with this pathology were analyzed. It has been shown that it is more preferable to use the GBT protocol for professional oral hygiene in patients with hemophilia.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):21-25
pages 21-25 views
Changes in the spectral properties of enamel in the diagnostics of periodontitis
Bazhutova I.V., Frolov О.О., Timchenko Е.V., Timchenko P.E.
  • The paper considers the possibility of early noninvasive diagnosis of periodontal diseases by using the method of Raman spectroscopy. The results of spectral studies of tooth enamel with periodontitis by means of this method are shown. It is proposed to use the obtained data for early non-invasive diagnostics of periodontitis.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):26-30
pages 26-30 views
Assessment of hygienic and periodontal status of patients after in-office tooth whitening
Magsumova O.A., Postnikov M.A., Tkach T.M., Polkanova V.A.
  • Nowadays, an increasing number of dentists support non-invasive methods of treatment of dental discoloration, one of which is the in-office teeth whitening procedure. When treating teeth discoloration and taking into account the aesthetic wishes of the patient, correction of the hygienic state of the oral cavity is important. The study involved 123 people aged 18 to 35 years with sanitized oral cavity and no somatic pathologies. The patients were divided into 3 groups depending on the type of the used whitening system. To assess the hygienic state of the oral cavity, the OHI-S index (Green–Vermillion) was used. The presence of the inflammatory process in the periodontal tissues and its intensity was checked using the gingival sulcus bleeding SBI index (Muhleman–Son). The indices were assessed 2 weeks before the office teeth whitening procedure, immediately before it, and 2 weeks, 6 and 12 months after the procedure. Teeth in-office whitening has a positive effect on oral hygiene. Good oral hygiene is noted both in the immediate and long-term follow-up, which is due to the high level of patient motivation. The study of the dynamics of the gingival bleeding index indicates the absence of the adverse effect of in-office teeth whitening on the condition of the periodontal soft tissues.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):31-36
pages 31-36 views
Study of the prevalence of anomalies of eruption of different groups of teeth in patients who have sought orthodontic care
Ishchenko E.A., Popov N.V.
  • BACKGROUND: Tooth impaction leads to many aesthetic and functional disorders and to the general deterioration in the quality of human life. Domestic and foreign scientists point at the increase in the number of medical consultations on this problem. Although the incidence of orthodontic care among patients with tooth impaction is extremely high, there is no consensus on the prevalence of impacted teeth.

AIM: To analyze the prevalence of dentition abnormality in various groups of patients who sought orthodontic care.

MATERIALS AND METHODS: The study was conducted at the clinical setting of the Department of Pediatric Dentistry and Orthodontics and the Department of Dentistry of IPE of Samara State Medical University in 2017-2020. A retrospective analysis of 423 medical records of orthodontic patients aged 18-32 years and a clinical examination of 134 dental patients aged 18-36 years were performed. A total of 557 patients were examined, including 236 women and 321 men.

RESULTS: A retrospective analysis of 423 case histories revealed impaction of 104 teeth of 72 patients (17.02%). A clinical examination of 134 orthodontic patients aged 18-36 years was conducted, 15 patients (11.19%) showed impaction of 23 teeth.

CONCLUSIONS: In the retrospective analysis of the upper jaw, molars were the predominant impacted teeth of 20 patients (62.5%), and canines were the second most frequently impacted teeth of 7 patients (21.88%). In the lower jaw, molars were also the most frequently impacted teeth in 59 patients (81.94%), and premolars occupied the second place among the most frequently impacted teeth in 8 patients (11.12%). Clinical examination of 134 orthodontic patients aged 18-36 years showed that 15 patients (11.19%) had impaction of 23 teeth. The majority of the impacted teeth were molars of the upper jaw (56,52%), and of the lower jaw (85,71). The second most frequently impacted teeth were maxillary canine teeth (26,09%) and mandibular canine teeth (14,29%).

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):37-40
pages 37-40 views
Сylindrical dental implant positioning devices
Ivashchenko A.V., Yablokov A.E., Vinnik S.V., Tlustenko V.P., Shestun E.M.
  • Modern digital technologies and their software open up new possibilities in dentistry. For example, the use of computed tomography is becoming more and more affordable. Almost every dental tomograph has the necessary software for 3D planning of dental procedures. Dental implantation has developed significantly in our country. The available surgical equipment make it possible to put dental implants even with the deficit of bone tissue. The purpose of this article was to summarize various methods to plan the placing the dental implant and to manufacture surgical templates. Dentistry has always been closely associated with other areas of science and industry, it tends to use a large number of modern innovations and developments. In this article, we have collected materials to demonstrate how the treatment process is changing in response to the integration of computer diagnostics and manufacturing (CAD / CAM) technologies. Consequently, we have more efficient and less traumatic dental implant planning systems based on the accurate data and computer calculations that minimize technological and human negative factors.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):41-48
pages 41-48 views
Increasing the efficiency of diagnostics of periodontal tissue diseases with modern research method
Vinnik A.V., Postnikov M.A., Lyamin A.V., Tkach T.M., Vinnik S.V.
  • Nowadays periodontal tissue diseases remain the leading dental pathology. Healthy periodontium is revealed only in 12% of people, while the rest have lesions of varying severity: from initial inflammatory to severe destructive changes with loss of teeth. Severe periodontitis, leading to the loss of teeth, is found in 5-15% of cases. To diagnose and prescribe treatment, laboratory assessment of the content of the gingival groove and / or periodontal pocket was studied. We assessed the titer of the aerobic and anaerobic microorganisms in the samples, the greatr amount was in a clinically significant titer. Although there are various instruments for taking the contents of the gingival groove and / or periodontal pocket, they have a number of drawbacks which complicate the culturing of the material and distort the findings. Taking into account the advantages and disadvantages of the existing instruments, we have developed the instrument for collecting the content of the gingival groove.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):49-53
pages 49-53 views
Prevalence of non-cavitated and manifest forms of caries in preschool children in Samara
Rozakova L.S.
  • Indices of the registration and evaluation of the severity of caries are useful tools in the estimation of both dental health among the population and the preventive dental programs advanced to the dentistry. The decay-missing-filled (DMF) index proposed by WHO in 1938 assumes the presence / absence of cavitated carious lesions of dentin, fillings and teeth extracted because of caries and its complications. A significant limitation of this indicator is the neglect of non-cavitated forms of caries, which make up 90 % of the pool of dental carious lesions. The purpose of the study was to assess the prevalence of non-cavitated and manifest forms of caries in preschool children in Samara. An epidemiological examination of the dental health of 4-8 years old children attending preschool and school educational institutions in Samara was performed. Totally 460 children were examined, of which 53 children (21 boys) were examined at the age of 4, 78 children (37 boys) at the age of 5, 178 (97 boys) at 6 years old, 78 (43 boys) at 7 years old, 73 (33 boys) at the age of 8 years. Two indices were used to assess the hard tissue damage caused by caries: the index of DMF of teeth and surfaces and the index of D0DMF of teeth and surfaces, the latter was proposed by the author. Our epidemiological study showed that the prevalence of dental caries in preschool children in Samara was 52.83%, 65.38%, 82.02%, 87.18%, 79.45% among 4, 5-, 6 -, 7- and 8-year-old children respectively. The prevalence of caries, taking into account non-cavitated forms, was 84.61%, 88.46%, 91.57%, 97.44% and 90.41% among 4, 5, 6, 7 and 8 year old children respectively. By the age of 8, 67.12% of children in Samara have permanent teeth with signs of developing caries (types without cavities). It suggests the necessity to start comprehensive programs for the prevention of caries in organized groups of children.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):54-59
pages 54-59 views
New method of index estimation of oral hygiene in patients undergoing orthodontic treatment with braces
Nikolaeva Y.V., Stepanov G.V.
  • Correction of the pathological position of teeth by means of braces has become more and more popular in recent years. Therefore it is very important to focus patients’ attention not only on timely access to the orthodontist, but also maintain good oral hygiene. It’s good oral hygiene within the period of orthodontic treatment that allows to achieve the best aesthetic result. The aim of our work was to determine the level of oral hygiene in patients undergoing orthodontic treatment with braces. A 1% solution of methylene blue was used as the indicator of plaque on teeth. 120 people (78 women and 42 men) with teeth malposition, undergoing treatment at the Department of Pediatric Dentistry of SamSMU were examined. Satisfactory conditions of oral hygiene was found in 41% (49 people) of patients with braces, good conditions in 29% (35 people), unsatisfactory conditions in 21% (25 people), and poor quality of hygiene in 9% of the patients (11 people). This information indicates that the majority of patients follow orthodontist’s recommendations about toothbrushing, but the presence of orthodontic equipment significantly complicates this manipulation. Therefore such patients are recommended to use additional devices for removing plaque from hard-to-reach areas, as well as professional oral hygiene at least once every 3-4 months.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):60-63
pages 60-63 views
In-vitro modeling of a biofilm of endoparodontal focus of infection
Ginnatulina S.I.
  • The development of the model of endoparodontal lesion in vitro is necessary due to the lack of the method for creating a biofilm of endodonto- and periodontopathogenic bacteria in vitro with the reconstruction of communication ways between the endodontium and the periodontium. We have proposed the method, the technical result of which is the maximal reconstruction of a multi-species mixed bacterial biofilm in tooth tissues in the environment similar to in vivo conditions, with the possibility of processing root canals and periodontal pockets in vitro. The proposed model is effective for the cultivation of obligate-anaerobic and facultative-anaerobic cultures.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):64-68
pages 64-68 views
Features of the course of comorbid somatic pathology depending on the method of treatment of lower jaw fracture without displacement of fragments
Moskalev E., Bayrikov I.M., Gubarevа I.V., Samikin A.S., Trusov Y.A., Zinkina A.A., Meshcheryakov Y.V.
  • AIM: The aim is to study the effect of the method of reducing the fractures of the mandible without displacement of fragments on the course of comorbid somatic pathology

MATERIALS AND METHODS: The study included 60 patients (45 men and 15 women) aged 18 to 69 years with fractures of the mandible without displacement of fragments and comorbid somatic pathology. The subjects were divided into three groups. The first group included 20 patients who received intraosseous orthodontic screws with intermaxillary rubber traction. The second group consisted of 20 patients who underwent immobilization with a Tigerstedt splint with intermaxillary rubber traction. The third group included 20 patients who underwent immobilization with a Vasiliev double-mandibular splint with intermaxillary rubber traction. We studied the effect of the method of reducing of fractures of the mandible without displacement of fragments on the course of comorbid somatic pathology.

RESULTS: As a result of the treatment in the first group, angina pectoris became unstable in 1 patient, which required a consultation with a cardiologist and correction of treatment. In the second group, in 3 patients (15%) with chronic polyarthrosis, prolonged wearing of dental splints resulted in the aggravation of deforming osteoarthritis of the TMJ and longer outpatient rehabilitation was required. In the third group, 13 patients (65%) with diabetes mellitus and ischemic heart disease demanded a prolonged oral tissue regeneration.

CONCLUSIONS: When choosing a method for reducing a fracture of the lower jaw, it is necessary to take into account the features of comorbid somatic pathology. The conservative method of treatment using dosed intermaxillary elastic traction is the most gentle.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):69-73
pages 69-73 views
Modern methods of treatment of dental retention: Literature review
Popov N.V., Shchukina I.Y., Eropkina A.O.
  • While analyzing statistical studies, a certain tendency in the increase of incidence of canine and premolar retention was revealed. The multifactorial nature of the development of this anomaly requires special attention. Dentists should be meticulous about the revealing of risk factors which can result in difficult teething, and about the resolving of the existing retention. The literature review presents modern methods and principles of treatment of canine and premolar retention. The first part of the literature review describes the etiopathogenetic factors that contribute to the development of retention, and the principles of treatment, depending on the severity of the clinical situation. In the second part of the review, a combined method of treatment of canine and premolar retention is described, the phasing of the performed measures and the predicted results are taken into account.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):74-81
pages 74-81 views
Changes in the oral microbiota during orthodontic treatment of 6-12 year-old children. Current state of the problem according to foreign researchers
Razilova A.V., Mamedov A.A., Simonova A.V.
  • The article is devoted to the analysis of foreign data from modern medical literature and the results of foreign clinical studies on the influence of various factors on changes in the oral microbiota in orthodontic treatment of 6-12 year-old children. The definition of the oral microbiota is given, its composition and functions are described in normal state and in orthodontic treatment with removable and non-removable devices in children of primary school age. The article presents research data confirming the importance of careful monitoring of the oral cavity during orthodontic treatment as a risk factor for inflammatory diseases of the oral mucosa, periodontal diseases and caries in primary school children.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):82-89
pages 82-89 views
The use of pneumatic dental drill in osteosynthesis in patients with fractures of the lower jaw
Soltanov A.D.
  • Nowadays the process of bone cutting and drilling is one of the important problems in maxillofacial surgery. Devices with a low power electric motor and an uncontrolled rotation speed of the work tool, as well as expensive devices such as Piezon-Master 400 are used to make holes during osteosynthesis, implantation and bone cutting in maxillofacial surgery. We have developed a special turbine pneumatic dental drill, which, can be an alternative to standard air turbine devices used in clinical practice when working on facial bones.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):90-93
pages 90-93 views
Clinical and epidemiological aspects of odontogenic phlegmon of the maxillofacial region: Data of the Maxillofacial Surgery Department of the Clinics of Samara State Medical University
Monakov V.A., Monakov D.V., Soldatkina J.А.
  • The article studies the prevalence of odontogenic inflammatory diseases of the maxillofacial region according to the data from the Department of Maxillofacial Surgery and Dentistry of the Clinics of Samara State Medical University. It was revealed that the incidence of diffuse inflammation depends upon the causative tooth, the incidence of out-patients visits. The morbidity depending on the age and sex of patients was studied. The incidence of odontogenic abscesses localized in various places was evaluated. Comorbidity in patients with odontogenic inflammatory processes was also investigated.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):94-99
pages 94-99 views
Anaerobic dysbiosis of the cervical canal as a risk factor for premature rupture of membranes
Kaganova M.A., Spiridonova N.V., Petyanova V.A., Denisova N.G., Syresina S.V., Petrov M.G., Rodionova N.A., Inyusheva L.S.
  • BACKGROUND: To identify the most significant predictors of premature rupture of membranes in full-term pregnancy with the use of RT-PCR analysis of cervical canal smear.

MATERIALS AND METHODS: On the basis of City Clinical Hospital No. 1 named after N.I. Pirogov (Samara), a cervical smear was examined by RT-PCR using a standard panel “Femoflor-16”. The study involved 47 pregnant women at 37-41 weeks of gestation: the control group consists of 19 pregnant women without premature rupture of the membranes (PROM), and 28 pregnant women with PROM, were included in the main group. The most significant risk factors of PROM were revealed with the use of the Classification Trees.

RESULTS: The following risk factors of PROM were identified: the number of Lactobacillus spp. less than 99.3% (sensitivity 75%, specificity 68%); total anaerobic microflora above 0.55% (sensitivity 71%, specificity 68%), Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp. more than 0.08% (sensitivity 64.3%, specificity 73.7%) and Megasphaera spp. / Veilonella spp. / Dialister spp. more than 0.06% (sensitivity 66.7%, specificity 52.6%). If at least one of the above criteria was identified, the patient was attributed to the high risk group for PROM; when all four indicators of the distribution of microorganisms are taken into account, the sensitivity of the method was 85.5%, specificity was 68.4%, the predictive value of positive and negative diagnostic results (models accuracy) were 78.7%.

CONCLUSIONS: The most prognostically significant risk factors for the development of PROM in the study of the cervical microbiota are the number of Lactobacillus spp. less than 99.3%; Gardnerella vaginalis / Prevotella bivia / Porphyromonas spp. more than 0.08%; Megasphaera spp. / Veilonella spp. / Dialister spp. more than 0.06%.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):100-109
pages 100-109 views
Evaluation of the efficiency of treatment with the domestic drug “Promisan” of patients with cervical intraepithelial neoplasia grade I
Suleimanova N.D., Kharkhachaeva S.M.
  • BACKGROUND: At present cervical cancer (CC) is one of the most common malignancies in women. The prevention of cervical cancer is early diagnosis and timely treatment of precancerous processes, which include cervical intraepithelial neoplasia (CIN).

AIM: To evaluate the clinical efficacy of treatment of patients with CIN I with the use of domestic drug “Promisan”.

MATERIALS AND METHODS: A total of 58 patients with CIN I were studied. They were divided into 4 groups (group I and group II are the treatment groups, group III and group IV are control groups). Group I included 16 patients who received treatment with the drug “Promisan” in conservative treatment. Group II included 18 patients who received complex treatment consisting of radio-wave excision of the cervix followed by the administration of Promisan. Group III included 14 patients with expectant treatment (without Promisan) and Group IV included 10 patients who underwent radio-wave excision of the cervix with subsequent dynamic observation (without Promisan).

RESULTS: Improvement in the CIN regression indices of the 1st degree, improvement in colposcopic data and regression / elimination of the human papillomavirus were revealed in a greater percentage in patients who received Promisan as monotherapy and as part of complex therapy compared to the control groups.

CONCLUSIONS: The results of the study make it possible to recommend Promisan for the prevention of cervical cancer in patients with dysplastic processes.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):110-116
pages 110-116 views
Approaches to the pharmacotherapy of diabetic macular edema: Literature review
Ionkina I.V., Grinev A.G., Zherebtsova O.M.
  • Pharmacotherapy of diabetic retinopathy and diabetic macular edema can be subdivided into groups according to the class of drugs, the most important of which are vascular endothelial growth factor inhibitors and corticosteroids. Intravitreal administration of these drugs is more preferable. The systemic use of angiotensin and fibrate receptor blockers is of least importance. The use of eye drops of non-steroidal anti-inflammatory drugs does not have convincing evidence of the efficacy in the treatment of diabetic macular edema. The article presents the results of the main studies on the development of algorithms for the treatment of diabetic retinopathy and diabetic macular edema.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):117-127
pages 117-127 views
Retinal vein occlusion: Modern approaches to treatment
Kukharskaya Y.I., Ivanova E.V., Volodin P.L.
  • Retinal vein occlusion (RVO) is the most common retinal vascular disease, it ranks second in terms of severity of retinal damage and prognosis after diabetic retinopathy. The main cause of visual impairment in patients with RVO is the manifestation of macular edema (ME). Persistent ME may block the recovering of visual acuity. The development of new methods of diagnosis and treatment of this pathology has changed approaches to the management of patients with RVO. This review presents the advantages and promising treatment modalities of retinal venous occlusions, it also demonstrates their advantages and disadvantages. Administration of drug treatment in the therapy of RVO is advisable only in the acute period of the disease. Laser coagulation is still the standard treatment for neovascular complications associated with RVO. The necessity of surgical repair remains controversial, since its use can result in severe complications, such as damage to the central retinal artery, perforation of the eye, retinal detachment and traumatic neuropathy. The use of steroids for the treatment of ME is associated with their ability to reduce capillary permeability, however, there is high risk of cataract. Antiangiogenic therapy is effective against pathogenesis of ME in RVO and is a first-line treatment for this disorder. The use of subthreshold microimpulse laser treatment is promising. Possibilities of further improvement and use of combined techniques in the treatment of this pathology are considered.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):128-138
pages 128-138 views
Balloon microcompression of gasserian ganglion in treatment of patients with trigeminal neuralgia
Lazarchuk D.M., Alekseev G.N., Suslin Y.V., Chernov G.N., Chemidronov S.N.
  • AIM: To determine the group of patients with trigeminal neuralgia for whom the balloon microcompression is the optimal treatment modality. To evaluate the effectiveness of balloon microcompression in the treatment of patients with trigeminal neuralgia.

MATERIALS AND METHODS: The study included 52 patients (18 men and 34 women) with trigeminal neuralgia who were operated with the use of balloon microcompression in neurosurgical department of the Samara Regional Clinical Hospital named after V.D. Seredavin over the period from February 2012 to June 2017. The evaluation of effectiveness was carried by Visual Analogue Scale, Macnub scale, the dose tapering of anti-epileptic medicines was also taken into account.

RESULTS: In postoperative period the decrease in pain syndrome was noticed by 48 patients (92.3%) from 90 ± 10 to 30 ± 10 points by Visual Analogue Scale. According to Macnub scale 29 patients (55.7%) estimated the level of treatment as “good”. 19 patients (36.5%) had negative emotional response due to the hypoesthesia, so the result was estimated as “satisfactory”. 39 patients (75%) managed to decrease the dosage of Finlepsin from 1000-1200 mg to 300-400 mg. Among them there were 8 patients (15%) who subsequently discontinued taking Finlepsin.

CONCLUSIONS: Balloon microcompression of Gasserian ganglion is a destructive-symptomatic method that must be considered the main modality only in patients with idiopathic trigeminal neuralgia or with contraindications for operative treatment. Balloon microcompression of Gasserian ganglion is a minimally destructive treatment mode, which allows to increase the effectiveness of treatment due to the alleviation of pain paroxysm in the area of trigeminal innervation and the decrease in dosage of anti-epileptic medicine.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):139-145
pages 139-145 views
Low-intensity extracorporal shockwave therapy for Peyronie’s disease
Gubanov E.S., Boryaev E.A., Stolyarov S.A., Zimichev A.A.
  • The article is devoted to the study of the effectiveness of low-intensity extracorporal shockwave therapy in the treatment of Peyronie disease. Fibroplastic induration of the penis, i.e Peyronie disease, is the one with poorly studied aetiology and pathogenesis. Treatment algorithm also needs to be studied. Literature review was performed. Examination and treatment of patients with the use of low-intensity extracorporeal shock wave therapy was performed. The results of our own research have confirmed the high efficiency and safety of the method.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):146-153
pages 146-153 views


Quantitative determination of anthracene derivatives in Aloe vera leaves: Technique development
Glushchenko S.N., Kurkin V.A., Shmygareva A.A., Sankov A.N.
  • AIM: The purpose of this work is to develop and use the method for the quantitative determination of Aloe vera leaves (Aloe vera L. ex Webb) using UV spectrophotometry.

MATERIALS AND METHODS: Since the method of quantitative determination of Aloe vera leaves in the State Pharmacopoeia of the Russian Federation XIV edition is not available, it was developed at the Department of Pharmaceutical Economics and Management, Pharmaceutical Technology and Pharmacognozy of Orenburg State Medical University. According to this method the optimal conditions for the extraction of anthracene derivatives in aloe vera leaves are the following: extractant was 96% ethyl alcohol); the ratio of “raw material and extractant” was 1:10; extraction time was the extraction in a boiling water bath for 30 minutes and 15 minutes in an ultrasonic bath. The registration of the spectra was performed with the use of Unico 2800 spectrophotometer in the wavelength range of 190-700 nm in cuvettes with the layer thickness of 10 mm, Vilitec VBS ultrasonic bath. The UV spectra of water-alcohol and alkali-ammonia solutions of Aloe vera leaves were investigated.

RESULTS AND DISCUSSION: The quantification of the of anthracene derivatives (calculated on barbaloin) in Aloe vera leaves was carried out with the use of methodology that determines anthracene derivatives directly in the test solution without acid hydrolysis and oxidation of anthraglycosides. The developed method of quantitative analysis allowed to determine the content of the total anthracene derivatives in terms of barbaloin in fresh leaves of aloe vera, the content ranged from 3.0-5.0% (calculated on dry-air plant material).

CONCLUSIONS: It was found that the content of the total anthracene derivatives in Aloe vera leaves calculated on barbaloin is 3.33%.

Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):154-159
pages 154-159 views
Main trends in optimization of pharmaceutical care for underage customers
Kuryleva M.A., Kirschina I.A.
  • The article presents the results of assessing the pharmaceutical literacy of underage visitors of pharmacies and analyzing the professional activity of pharmaceutical workers when dealing with underage customers. Insufficient level of knowledge necessary for making meaningful purchases of medicines and other pharmaceutical products in underage customers was revealed. A sociological survey of pharmaceutical workers has shown that in most cases when children and adolescents come to pharmacy organizations, specialists are forced to contact their parents and / or other adults to clarify the necessary information about the purchased pharmaceutical products. The analysis has shown the need to adapt pharmaceutical counseling to the age characteristics of children and adolescents and the feasibility of pharmaceutical education in order to prevent pharmaceutical risks in this age group. The findings allowed to develop methodological approaches to the organization of pharmaceutical assistance for children and adolescents in pharmacy organizations, and organizational measures aimed at improving the pharmaceutical literacy of the younger generation from the point of view of pharmaceutical safety were identified.
Aspirantskiy Vestnik Povolzhiya. 2021;21(1-2):160-166
pages 160-166 views

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